DNA Cardiovascular Health Test

What are cardiovascular diseases?
Cardiovascular disease refers to a large spectrum of disorders, many of which involve narrowed or blocked blood vessels, leading to chest pain (angina), heart attacks and strokes. Cardiovascular diseases are the leading cause of death (over 30% of all deaths worldwide).

Factors that affect cardiovascular health
Both lifestyle and genetic factors can lead to abnormal levels of cholesterol, triglycerides, CRP and lipoproteins in the body, resulting in a greatly increased risk of life-threatening cardiovascular disease.

  • Cholesterol – A fat-like substance that is produced in our body and obtained from some foods. It is transported around the body in two kinds of lipoproteins – HDL and LDL. Reduced “good” HDL-cholesterol or excess “bad” LDL-cholesterol leads to cholesterol accumulation in the arteries, resulting in narrowed or blocked blood vessels.
  • Triglycerides – Obtained from the digestion and breakdown of fats in food and making up the majority of fat deposits in the body. Excess triglycerides contribute to obesity and heart disease.
  • C-reactive protein (CRP) – A substance produced by the liver that increases during an inflammatory response. Elevated CRP levels can lead to heart disease.
  • Lipoprotein(a) – A type of lipoprotein similar to “bad” LDL. It is rich in cholesterol and excess levels increase the risk of cardiovascular disease.
NOTE: This test will be available mid 2018
Genetics of cardiovascular health
Genetic variations can affect your cholesterol (HDL- and LDL-cholesterol), triglycerides, lipoprotein(a), C-reactive protein and cell proliferation. Many genetic variants influence both cholesterol and triglyceride levels, with some variants increasing the risk of cardiovascular disease, while others have a protective effect. The following table lists the genes analyzed in the cardiovascular health test, and the effect of variation on cardiovascular health.

Gene(s) Tested Effect
ANGPTL4, APOA5, FADS1, GALNT2, HNF4A, LIPG, MMAB Reduced “good” HDL-cholesterol
CETP, LCAT, LIPC, LPL Elevated “good” HDL-cholesterol
APOB, FADS1, LDLR, NCAN, PCSK9, SORT1, SUGP1 Reduced “bad” LDL-cholesterol
HMGCR, HNF1A, TRIB1 Elevated “bad” LDL-cholesterol
LPA Elevated lipoprotein(a)
CRP, GCKR Elevated C-reactive protein (CRP)
APOA5, FADS1, GALNT2, GCKR, NOS3, TRIB1 Elevated triglycerides
ANGPTL3, LPL, MLXIPL, NCAN Reduced triglycerides
9p21 Decreased control of cell proliferation
Suggested Retail Price = $349 USD. This price includes the laboratory fee, results report and all associated postage.

A simple mouth swab is all that is required to collect an individual’s DNA sample.

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